Media Resources

EicOsis has Developed a New Class of Oral, Non-Opioid Pain Therapy and Is Advancing It to Human Clinical Trials

At EicOsis we are responding to the pressing need for safe, effective and non-addictive treatments for those struggling with pain. EicOsis has received funding through competitive grants from federal agencies and angel investors and has recently advanced its lead drug candidate for pain to first-in-human clinical trials. Learn more about what is going on at EicOsis through our most recent press releases. Don’t forget to sign up to receive all our news and updates!

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EicOsis drug candidate for pain, EC5026, is currently undergoing clinical trials

November 2020: EicOsis Successfully Completes Phase 1a Clinical Trial of EC5026

EicOsis Human Health announced the successful completion of a Phase 1a single-ascending dose clinical trial of EC5026, their oral drug candidate for the treatment of pain. No drug-related adverse events or changes in vital signs or clinical labs were observed, and the final clinical study report concludes that EC5026 is safe and well tolerated when given as a single oral dose ranging from 0.5 to 24 mg. The pharmacokinetic profile indicates that EC5026 is suitable for once daily oral dosing. Read more.

April 2020: EicOsis EC5026 has been Granted Fast Track Designation by the FDA for the treatment of neuropathic pain

EicOsis LLC announced today that the U.S. Food & Drug Administration (FDA) has granted Fast Track designation to its lead drug candidate, EC5026, for the treatment of neuropathic pain. Fast Track designation confers important benefits, including the potential eligibility for Priority Review of a New Drug Application. Read more.

December 2019: EicOsis Announces First Subject Dosed in the First Phase 1a Clinical Trial of EC5026

EicOsis LLC today announced initiation of dosing for the first human subject in a Phase 1 trial of EC5026, the company’s lead product candidate for pain management. This Phase 1a, single-ascending dose trial will evaluate the safety and tolerability of single oral doses of EC5026 in healthy volunteers. Read more

October 2019: EicOsis Announces FDA Acceptance of IND Application for EC5026, the First Soluble Epoxide Hydrolase Inhibitor to Treat Pain

EicOsis LLC, a pharmaceutical startup developing a new class of oral non-narcotic analgesics based on inhibition of the soluble epoxide hydrolase (sEH) enzyme, announced today that the U.S. Food and Drug Administration (FDA) has approved the Investigational New Drug (IND) application to initiate Phase 1 clinical trials for their drug candidate, EC5026 (BPN-19186), for the treatment of pain. EicOsis anticipates starting Phase 1 clinical trials in healthy volunteers before the end of this year. Read more

August 2019: The structure of the sEHI for human pain trials was presented at the First Time Disclosure Symposium at the Fall American Chemical Society Meeting.

EicOsis revealed the chemical structure of EC5026 – the first soluble epoxide hydrolase (sEH) inhibitor targeting pain to make it into human clinical trials. The molecule was disclosed at the American Chemistry Society national meeting on August, 2019. Read more

EicOsis in Bloomberg – Business Week on Opioid Replacements for Pain Treatment

EicOsis is developing a completely new therapeutic approach for the treatment of pain. EicOsis new drug is aiming at replacing and reducing the use of opioids.  Read more

EicOsis has been awarded over 20 million in competitive grants

October 2019: EicOsis Announces SBIR Grant Award from NCI/NIH

The National Institute of Health has awarded a Small Business Innovation Research (SBIR) grant from the National Cancer Institute to EicOsis, LLC to support preclinical testing of soluble epoxide inhibitors for treating neuropathic pain associated with chemotherapy drugs. Read more

October 2019: EicOsis Receives $15 million from NIDA to Help Fund Trials of Non-opioid Pain Therapy

The National Institute on Drug Abuse has awarded a grant to EicOsis, LLC as part of the NIH Initiate Helping to End Addition Long-Term (HEAL Initiative) to support human clinical trials of a novel compound that has been found effective for the treatment of pain in preclinical animal studies. Read more

March 2019: EicOsis Raises funding for Phase 1 Clinical Development Program of Novel Pain Therapeutic

EicOsis Human Health recently received a $5 million investment from Open Philanthropy to support clinical trials on a novel, non-opioid, oral therapy for neuropathic and inflammatory pain. Read more

January 2016: EicOsis Receives $4 Million to Develop Novel Treatment for Diabetic Neuropathic Pain

EicOsis, LLC was awarded a federal grant totaling over $4 million to advance compounds through Phase 1 clinical trials for diabetic neuropathic pain. The grant, “Development of an Oral Analgesic for Neuropathic Pain”, is funded through The National Institutes of Health (NIH) Blueprint for Neuroscience Research. Read more

EicOsis is an innovation leader in the local community

November 2019: EicOsis Named Sacramento’s Most Innovative BioPharma Company

EicOsis was awarded the 2019 Sacramento Region Innovation Award in Medical & Health – Biopharma for developing a first-in-class, non-opioid therapy for treatment of inflammatory and neuropathic pain in humans and companion animals. Read more