The scientific developments behind sEH inhibitors are the result of more than 30 years of collaborative research between Dr. Bruce Hammock’s laboratory and the Veterinary and Medical facilities of the University of California, Davis, world renowned for their work in veterinary medicine and clinical trials. At EicOsis, we have a chemical library exceeding 3,000 compounds that target the sEH enzyme and we have optimized efficacy for humans and several species to relieve pain.
Highlighted Scientific Papers
More Available Scientific Papers
Below is a list of scientific papers describing research history of EicOsis.
- Inceoglu, B.; Jinks, S. L.; Ulu, A.; Hegedus, C. M.; Georgi, K.; Schmelzer, K. R.; Wagner, K.; Jones, P. D.; Morisseau, C.; Hammock, B. D. 2008. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proceedings of the National Academy of Sciences of the United States of America. 105 (48). 18901–18906.
- Hammock, B. D.; Wagner, K.; Inceoglu, B. 2011. The soluble epoxide hydrolase as a pharmaceutical target for pain management. Pain Management. 1 (5). 383–386.
- Inceoglu, B.; Wagner, K.; Schebb, N. H.; Morisseau, C.; Jinks, S. L.; Ulu, A.; Hegedus, C.; Rose, T.; Brosnan, R.; Hammock, B. D. 2011. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proceedings of the National Academy of Sciences of the United States of America. 108 (12). 5093–5097.
- Morisseau, C.; Inceoglu, B.; Schmelzer, K.; Tsai, H.-J.; Jinks, S. L.; Hegedus, C. M.; Hammock, B. D. 2010. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. Journal of lipid research. 51 (12). 3481–3490.
- Wagner K, Yang J, Inceoglu B and Hammock BD. 2014. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain. 15(9) 907-914 PMID: 24924124.
- Inceoglu, B.; Wagner, K. M.; Yang, J.; Bettaieb, A.; Schebb, N. H.; Hwang, S. H.; Morisseau, C.; Haj, F. G.; Hammock, B.D. 2012. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 109 (28). 11390–11395.
- Wagner, K.; Inceoglu, B.; Dong, H.; Yang, J.; Hwang, S. H.; Jones, P.; Morisseau, C.; Hammock, B. D. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. European journal of pharmacology. 700 (1-3). 93–101.
- Wagner, K.; Inceoglu, B.; Hammock, B. D. 2011. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins & other lipid mediators. 96 (1-4). 76–83.
- Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 21;112(29):9082-7. doi: 10.1073/pnas.1510137112. Epub 2015 Jul 6. PMCID: PMC4517273 (avail 1/21/2016)
- Sasso, O., K. Wagner, C. Morisseau, A.B. Inceoglu, B.D. Hammock and D. Piomelli. 2015 July. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 97:7-15. PMCID: PMC4464910 (avail 7/1/2016)
- Hwang SH, Wecksler AT, Wagner K, Hammock BD. 2013. Rationally Designed Multitarget Agents Against Inflammation and Pain. Current Medicinal Chemistry. 20: 1783-1799.
- Inceoglu, A.B., D. Zolkowska, H.J. Yoo, K.M. Wagner, J. Yang, E. Hackett, S.H. Hwang, K.S.S. Lee, M.A. Rogawski, C. Morisseau and B.D. Hammock. 2013 Dec. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One. 8(12):e80922. PMID: 24349022. PMCID: PMC3862847
- Guedes, A. G.; Morisseau, C.; Sole, A.; Soares, J. H.; Ulu, A.; Dong, H.; Hammock, B. D. 2013. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Veterinary anaesthesia and analgesia . 2013 Mar 7. doi: 10.1111/vaa.12030.
- Wagner, K.; Inceoglu, B.; Gill, S. S.; Hammock, B. D. 2011. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. Journal of agricultural and food chemistry. 59 (7). 2816–2824.
- Hwang, S. H.; Wagner, K. M.; Morisseau, C.; Liu, J.-Y.; Dong, H.; Wecksler, A. T.; Hammock, B. D. 2011. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of medicinal chemistry. 54 (8). 3037–3050.
- Wagner, K., S. Vito, B. Inceoglu and B.D. Hammock. 2014. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat. 113-115(2014):2-12. PMCID: PMC4254344
- Rose, T. E.; Morisseau, C.; Liu, J.-Y.; Inceoglu, B.; Jones, P. D.; Sanborn, J. R.; Hammock, B. D. 2010. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. Journal of medicinal chemistry. 53 (19). 7067–7075.
- Inceoglu, B.; Schmelzer, K. R.; Morisseau, C.; Jinks, S. L.; Hammock, B. D. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins & other lipid mediators. 82 (1-4). 42–49.
- Inceoglu, B.; Jinks, S. L.; Schmelzer, K. R.; Waite, T.; Kim, I. H.; Hammock, B. D. 2006. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life sciences. 79 (24). 2311–2319.
- Schmelzer, K. R.; Inceoglu, B.; Kubala, L.; Kim, I.-H.; Jinks, S. L.; Eiserich, J. P.; Hammock, B. D. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 103 (37). 13646–13651.
